My first response is usually to slow down and figure out what is actually causing the damage before trying to treat it. Holes in leaves, chewed stems, missing seedlings, and disturbed soil can all look similar at first, but the solution is very different if you are dealing with slugs, caterpillars, rabbits, squirrels, or something larger.
I check the plants early in the morning and again near dusk, look under leaves, and pay attention to the pattern of damage. Cleanly clipped stems usually point to an animal. Ragged leaf damage may be insects or slugs. Tracks, droppings, webbing, and chewed edges can tell you more than the damaged plant itself.
The rule that has reduced the most damage for me is: block access before reaching for a spray. For a small vegetable or flower garden, that can mean row covers, netting, wire mesh around vulnerable plants, or collars around young stems. Physical barriers are especially useful because they deal with the problem at the source without adding something to the garden that children, pets, pollinators, or beneficial insects might encounter.
I also try to keep the area tidy. Fallen fruit, open compost, standing water, and dense weeds can all make the garden more inviting to pests. If a plant is repeatedly targeted, I will move it, protect it more deliberately, or accept that it is in the wrong location rather than repeatedly treating the same issue.
Chemicals are not my first move. If a pest problem becomes serious enough to require a product, I would choose the least-toxic option that specifically addresses the pest, follow the label exactly, and keep pets and people out of the treated area for the stated period. But in most home gardens, regular inspection and a good physical barrier solve more than people expect. Integrated pest-management guidance similarly emphasizes monitoring and identification first, then prevention and lower-risk controls such as barriers or hand removal.